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Journal: BMC Complementary Medicine and Therapies
Article Title: Nanoparticles from grape seed extract inhibit inflammatory cytokines and ameliorate CCl 4 -induced hepatotoxicity
doi: 10.1186/s12906-025-05005-7
Figure Lengend Snippet: Biochemical and oxidative stress parameters in the different experimental groups. Levels of A ] alanine transaminase (ALT), B ] aspartate transaminase (AST), C ] alkaline phosphatase (ALP) in serum, D ] malondialdehyde (MDA) and E] Superoxide dismutases (SOD), F] Glutathione (GSH) and G ] Catalase in liver homogenate measured following 30 days of treatment. HCs, negative control group; vehicle control, receives olive oil only; CCl 4 -untreated, liver injury rats that receive 100 µl CCL 4 , at a dose of 0.5 ml/kg, dissolved in olive oil twice a week for three successive weeks; CCl4-GSE, rats with CCL 4 -induced liver injury that receive grape seed extract (200 mg/kg/day) by oral gavage for four weeks; CCl 4 -GSENPs, rats with CCL 4 -induced liver injury that receive grape seed extract nanoparticles (100 mg/kg/day) by oral gavage for four weeks. Data were expressed as mean ± S.D ( n = 5/ subgroup). Statistical analysis was carried out by one-way ANOVA followed by post-hoc Turkeyʼs test. Values marked with the same letter are not significantly different ( p ≥ 0.05) whereas those marked with different ones are significantly differed ( p < 0.05)
Article Snippet: Malondialdehyde (MDA) level and the antioxidant enzymatic activity of
Techniques: Negative Control, Control